Serum levels of doxycycline in normal subjects after a single oral dose.

he was taking a minimum of 256 units daily. Thereafter the dosage dropped progressively, but seven weeks later he still needed up to 188 units daily. He was then transferred to Actrapid MC. In three days his insulin requirement fell by 36 % to 102 units daily. He was stabilised on twice daily Actrapid MC in a total dose of 112-124 units daily and remained well controlled, with a mean mid-morning blood sugar level of 6-1 mmol/l (110 mg/ 100 ml). His daily diet (9-2 MJ; 2200 kcal) and weight remained unchanged. At the time of maximum insulin resistance there was no evidence of severe infection or any other precipitating factor; in particular, his growth hormone levels were normal.